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Obesity --- Social Environment --- Exercise --- Health Policy --- Obésité --- epidemiology --- prevention & control --- Health aspects --- Prevention. --- Aspect sanitaire --- Prévention --- Zwaarlijvigheid --- Obésité --- Prévention --- Social Environment. --- Exercise. --- Health Policy. --- epidemiology. --- prevention & control.

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Bone metastases continue to be a major cause of morbidity in cancer patients, but improved understanding of the biology of bone metastases has led to the identification of drugs that are of potential value in not only their treatment but also their prevention. This book, written by recognized experts in the field, provides a detailed overview of current knowledge on this subject. One important focus of the book is the efficacy of bisphosphonates in preventing bone metastases in patients with breast, lung, and prostate cancer and disease progression in cases of multiple myeloma.  The combined use of bisphosphonates and cytostatics is also discussed, with a report on first clinical data.  Further topics addressed include the significance of the bone microenvironment, special issues in the elderly patient, the use of bone turnover markers, and initial findings obtained with denosumab.

Oncology. Neoplasms --- oncologie --- Bone Neoplasms --- Biomarkers. --- Cytostatic Agents --- Diphosphonates --- Bones --- Bone metastasis --- Os --- Métastases osseuses --- prevention & control. --- secondary. --- therapeutic use. --- Cancer --- Prevention --- Prévention --- EPUB-LIV-FT LIVMEDEC SPRINGER-B

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'Rare Diseases Epidemiology' offers numerous approaches to increase the knowledge base of rare diseases and conditions and to facilitate the development and dissemination of interventions for the prevention, diagnosis, or treatment of over 6500 diseases and conditions. The goals of epidemiology are not restricted merely to providing numerical data on the prevalence or incidence of diseases in a limited or general population. Analyses of epidemiological data gathered from appropriately designed and conducted studies are required to establish public health policies and priorities in all nations. Information gained from these studies lead to a better understanding of the etiology and the impact of genetic or environmental factors on the occurrence and outcome of these disorders. The term Rare Diseases includes both acquired and inherited disorders. 'Rare Diseases Epidemiology' provides methods and approaches from the collective experiences of established research investigators who address these significant issues of the development of patient registries; the collection, storage and selected distribution of bio-specimens from bio-banking activities; the validation and utilization of genetic testing and newborn screening procedures; the presentation of issues related to the importance of case reports to increase knowledge of rare diseases; the challenges and models for population-based surveillance studies for rare congenital and inherited disorders; the statistical methods for the geographical analyses of rare diseases; the value and need for clinical trials and comparative effective studies; and meeting the requirements of regulatory agencies. Economic, societal, and ethical concerns are presented as patients and families encounter difficulties obtaining the correct diagnosis, gaining access to treatments, and receiving coverage or reimbursement for approved interventions, and for developing a public understanding of the costs to patients and their families and the burden of illness affecting the quality of life of millions of patients with rare diseases and conditions. Framework programs for rare diseases research as developed by the European Union and the value of national plans for individual member countries are discussed and represent the public commitment to patients with rare diseases. Likewise, similar programs have been implemented in the USA as a result of the Orphan Drug Act to address the needs of the rare diseases community.

Medicine & Public Health. --- Epidemiology. --- Human Genetics. --- Health Promotion and Disease Prevention. --- Medicine. --- Human genetics. --- Médecine --- Génétique humaine --- Epidémiologie --- Rare diseases --- Rare disorders --- Uncommon diseases --- Diseases --- Epidemiology

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Doping in sports and the fight against it has gained increasing attention in recent years. The pharmacological basis for a possible performance enhancement in competitive sport through the administration of prohibited substances and methods as well as the analytical disclosure of such practices are comprehensively covered in 21 contributions by outstanding and distinctive authors.

Biomedicine. --- Pharmacology/Toxicology. --- Medical Biochemistry. --- Sports Medicine. --- Forensic Science. --- Pharmacy. --- Medicine. --- Toxicology. --- Forensic medicine. --- Biochemistry. --- Sports medicine. --- Médecine --- Toxicologie --- Pharmacie --- Biochimie --- Médecine du sport --- Doping in sports --- Doping in sports. --- Sports --- Steroids --- Doping in Sports --- Substance Abuse Detection --- Anabolic Agents --- Prevention. --- Drug use. --- Side effects. --- prevention & control. --- methods. --- adverse effects.

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Brain injury remains one of the most dreaded complications of cardiac surgery. The range of injury is broad; while a stroke may be easily defined and diagnosed, more subtle injuries most definitely occur. There remains debate as to how these are diagnosed and there is a lack of standard definitions allowing inter-study comparison. If we are to have confidence in strategies that may reduce brain injury, we need to have confidence in the end-points used to define that injury. We need to better understand the phenomena associated with neuropsychometric testing; we need to fully elucidate the relationship between structural brain injury, embolism counting, and surrogate biomarkers; and we need an improved understanding of the clinical significance of abnormalities detected on postoperative magnetic resonance imaging. Brain Protection in Cardiac Surgery presents a detailed background of studies of neurological morbidity and neuroprotection from a range of experts in the field of neuroprotection, providing a detailed reference for clinicians in the field. The Editors have detailed connections between the different strands of injury be it the pathology, the imaging, the clinical and cognitive examination, potential biomarkers and have then provided summary reports of treatment strategies that may reduce such injury. As we look to the future, the design of studies attempting to reduce such injury becomes increasingly important and this book provides the fundamental background information to fuel interest, initiate novel prevention and therapeutic strategies, and inform the investigator how to develop and design their research study.

Neuropathology --- medische beeldvorming --- cardiologie --- neurologie --- Surgery --- hersenen --- Human medicine --- Radiotherapy. Isotope therapy --- radiologie --- hartchirurgie --- geneeskunde --- Pathology of the circulatory system --- Physical methods for diagnosis --- Brain Injuries --- Cardiovascular Surgical Procedures. --- Intraoperative Complications. --- Heart --- Brain damage --- Coeur --- Cerveau --- prevention & control. --- Complications --- Prevention --- Chirurgie --- Complications et séquelles --- Lésions et blessures --- Prévention --- EPUB-LIV-FT LIVMEDEC SPRINGER-B